Research Guide · Laboratory Use Only
IGF-1 LR3 (Long R3 IGF-1) is a modified, long-acting analog of insulin-like growth factor 1 — the key mediator of many of growth hormone’s downstream effects.
What it is
The R3 substitution and N-terminal extension reduce binding to IGF-binding proteins, which in research models extends the analog’s active half-life relative to native IGF-1. It signals through the IGF-1 receptor.
How it’s studied
It is studied for cell growth and proliferation pathways and as a downstream counterpart to GH-secretagogue research.
Research focus areas
- IGF-1 receptor signaling
- Reduced IGF-binding-protein interaction
- Cell growth and proliferation models
- Downstream link to the GH axis
Handling & documentation
In the laboratory this material is typically supplied as a lyophilized (freeze-dried) powder and reconstituted with bacteriostatic or sterile water for in-vitro work. As with any research compound, the quality signal that matters most is a lot-specific Certificate of Analysis (COA) from an independent lab, confirming identity by mass spectrometry and purity by HPLC. Store per the supplier’s guidance and verify the COA before use.
Browse the COA-verified research catalog →
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